Linux
Here are some known Linux-specific issue that can happen to PCSX2
libfuse2
If you see an error when opening the AppImage such as the following:
...
dlopen(): error loading libfuse.so.2
...
Then you need to install libfuse2
in order to the run the AppImage in your environment. Recent versions of Ubuntu (22.04+) have switched to libfuse3, which is not backwards compatible.
sudo apt install libfuse2